Metabolic Research, Inc., of Las Vegas, Nevada, has developed a male and female formula for rapid body building using adult stem cell recruitment in conjunction with circadian body rhythms differentiated between waking and sleep states. The circadian formulas are combined with essential nutrients and fatty acids that regulate metabolic process of mitochondrial gene expression, growth factors and protein synthesis. The following discussions explains the benefits of using a circadian, binary fitness supplement.

Circadian rhythms regulate the metabolism of all higher organisms. In man, the body shifts into a quiescent state during sleep, which facilitates cellular repair and rebuilding of body tissues. When awake the body operates its metabolism at a much higher rate than when sleeping. Blood pressure, heart rate, breathing, and brain activity operate at a much higher rate requiring most of the available energy of the body. This heightened activity leaves little energy for replenishing vital protein, nutritional, cellular repair, and hormone stores for vitality, down regulation of localized inflammatory states, muscle growth and cellular repair, which are necessarily carried out during sleep. This is why sleep is so vital to the maintenance of good health.

During sleep the liver, kidneys, and other organs typically detoxify the accumulation of ingested, internally manufactured, and inhaled toxins. As heart rate slows and blood pressure drops during sleep, the pressure differential in the extra-cellular spaces allow the cells to expel toxins from the cytoplasm into the interstitial spaces where the lymph and venous systems pick them up and carry them to liver, kidneys and gut for elimination. When one dreams in what is called REM sleep, the body is actually in a paralytic state, unable to move. A great deal of emotional adjustment and brain repair is carried out in REM sleep.

During sleep the limbic brain activates vital signals to the hypothalamus gland, pituitary gland and adrenal glands complex (called the HAP complex), the key regulator of mitochondrial function and coordinator of the cell’s nuclear and mitochondria gene expressions.

The hypothalamus is the key to homeostasis and parasympathetic functions such as breathing, body temperature, food and water intake, and stimulation of the gastrointestinal tract. The pituitary controls growth hormone release, sexual glands and the function of the adrenal glands, which produce steroids such as adrenalin, epinephrine, and cortisol. These steroids down regulate the effects of inflammation as well as the perception of pain, fatigue, and mental alertness.