Stemulite® Exercise Fitness Products

Metabolic Research, Inc., of Las Vegas, Nevada, has developed a male and female formula for rapid body building using adult stem cell recruitment in conjunction with circadian body rhythms differentiated between waking and sleep states. The circadian formulas are combined with essential nutrients and fatty acids that regulate metabolic process of mitochondrial gene expression, growth factors and protein synthesis. The following discussions explains the benefits of using a circadian, binary fitness supplement.

Circadian rhythms regulate the metabolism of all higher organisms. In man, the body shifts into a quiescent state during sleep, which facilitates cellular repair and rebuilding of body tissues. When awake the body operates its metabolism at a much higher rate than when sleeping. Blood pressure, heart rate, breathing, and brain activity operate at a much higher rate requiring most of the available energy of the body. This heightened activity leaves little energy for replenishing vital protein, nutritional, cellular repair, and hormone stores for vitality, down regulation of localized inflammatory states, muscle growth and cellular repair, which are necessarily carried out during sleep. This is why sleep is so vital to the maintenance of good health.

During sleep the liver, kidneys, and other organs typically detoxify the accumulation of ingested, internally manufactured, and inhaled toxins. As heart rate slows and blood pressure drops during sleep, the pressure differential in the extra-cellular spaces allow the cells to expel toxins from the cytoplasm into the interstitial spaces where the lymph and venous systems pick them up and carry them to liver, kidneys and gut for elimination. When one dreams in what is called REM sleep, the body is actually in a paralytic state, unable to move. A great deal of emotional adjustment and brain repair is carried out in REM sleep.

During sleep the limbic brain activates vital signals to the hypothalamus gland, pituitary gland and adrenal glands complex (called the HAP complex), the key regulator of mitochondrial function and coordinator of the cell’s nuclear and mitochondria gene expressions.

The hypothalamus is the key to homeostasis and parasympathetic functions such as breathing, body temperature, food and water intake, and stimulation of the gastrointestinal tract. The pituitary controls growth hormone release, sexual glands and the function of the adrenal glands, which produce steroids such as adrenalin, epinephrine, and cortisol. These steroids down regulate the effects of inflammation as well as the perception of pain, fatigue, and mental alertness.

It appears that many of these functions are either greatly diminished when awake or function only during sleep. Therefore, the use of dietary supplements solely during the day could be relatively ineffective.

This could be especially true for protein, peptides, amino acids, essential fatty acids, and hormone supplements, which are combined with digestion and under metabolized by the body during the awake state for daily activity, (analogous to trying to repair your car while it is running) many of which are simply excreted out of the system before the body can take full advantage of them.

The supplement makes use of Lipoic acid to facilitate the electron transport of beta oxidation to the mitochondrial enhancing gene expression of DNA for new muscle tissue. All of the above processes are much more active and efficient during sleep than when the body is active with increased metabolism, digestion of food, continuous daily activity.

Take human growth hormone, for example. The circadian supplement for accelerated muscle mass uses a natural acetylcholine receptor (AChR) agonist to stimulate quiescent adult stem cell mobilization, and combines it with amino acid, L-carnitine to reduce muscle damage from a hypoxic workout. The combination produces natural anabolic hormone release of human growth hormone, (HGH) insulin-like growth factor (I GF), insulin-like growth factor binding protein (IGFBP), and testosterone for the workout.

Although these growth factors and stem cells are stimulated during the workout, the real effect comes when they are again stimulated at night for maximum effectiveness.

When the workout is designed to exercise a specific muscle group (say, the pectorals) to exhaustion, the resulting hypoxic condition causes release of certain peptides called hypoxic inducible factor (HIF) that mobilize sleeping adult stem cells from the bone marrow which are recruited to the workout zone by stem-cell factors such as HIF and vascular endothelial growth factor (VEGF), nitric oxide (NO) synthase, and other unelucidated factors. Once stem cells are in the workout zone they immediately begin to replicate into identical muscle cells and build new blood vessels to supply nutrients to the new muscle-cell population. These juvenile muscle cells continue to multiply and mature into fully developed striated muscle cells.

The product is divided into two doses, one to take care of the workout needs for down regulation of inflammatory responses to micro-tears, strains and cell exhaustion, and an evening dose to induce gentle sleep while a new dose of muscle-building supplements is provided for complete tissue recovery and replenishing of protein stores.

The female product contains a natural estrogenic bio-identical hormone derived from Mexican Yam to reduce the exercise loss of fibro glandular tissue in the breast, while increasing the loss of adipose fat and omental fat in the belly, hips and thighs.

In summary, circadian dietary supplements are designed to take advantage of the circadian body rhythms and offer many advantages over conventional supplements designed for once-per-day use.