Stemulite® Exercise Fitness Products

Stemulite Fitness Formula For Men and
Stemulite Fitness Formula For Women

Metabolic Research, Inc., of Las Vegas, Nevada, has developed a male and female formula for rapid body building using adult stem cell recruitment in conjunction with circadian body rhythms differentiated between waking and sleep states. The circadian formulas are combined with essential nutrients and fatty acids that regulate metabolic process of mitochondrial gene expression, growth factors and protein synthesis. The following discussions explains the benefits of using a circadian, binary fitness supplement.

Circadian rhythms regulate the metabolism of all higher organisms. In man, the body shifts into a quiescent state during sleep, which facilitates cellular repair and rebuilding of body tissues. When awake the body operates its metabolism at a much higher rate than when sleeping. Blood pressure, heart rate, breathing, and brain activity operate at a much higher rate requiring most of the available energy of the body. This heightened activity leaves little energy for replenishing vital protein, nutritional, cellular repair, and hormone stores for vitality, down regulation of localized inflammatory states, muscle growth and cellular repair, which are necessarily carried out during sleep. This is why sleep is so vital to the maintenance of good health.

During sleep the liver, kidneys, and other organs typically detoxify the accumulation of ingested, internally manufactured, and inhaled toxins. As heart rate slows and blood pressure drops during sleep, the pressure differential in the extra-cellular spaces allow the cells to expel toxins from the cytoplasm into the interstitial spaces where the lymph and venous systems pick them up and carry them to liver, kidneys and gut for elimination. When one dreams in what is called REM sleep, the body is actually in a paralytic state, unable to move. A great deal of emotional adjustment and brain repair is carried out in REM sleep.

During sleep the limbic brain activates vital signals to the hypothalamus gland, pituitary gland and adrenal glands complex (called the HAP complex), the key regulator of mitochondrial function and coordinator of the cell’s nuclear and mitochondria gene expressions.

The hypothalamus is the key to homeostasis and parasympathetic functions such as breathing, body temperature, food and water intake, and stimulation of the gastrointestinal tract. The pituitary controls growth hormone release, sexual glands and the function of the adrenal glands, which produce steroids such as adrenalin, epinephrine, and cortisol. These steroids down regulate the effects of inflammation as well as the perception of pain, fatigue, and mental alertness.

It appears that many of these functions are either greatly diminished when awake or function only during sleep. Therefore, the use of dietary supplements solely during the day could be relatively ineffective.

This could be especially true for protein, peptides, amino acids, essential fatty acids, and hormone supplements, which are combined with digestion and under metabolized by the body during the awake state for daily activity, (analogous to trying to repair your car while it is running) many of which are simply excreted out of the system before the body can take full advantage of them.

The supplement makes use of Lipoic acid to facilitate the electron transport of beta oxidation to the mitochondrial enhancing gene expression of DNA for new muscle tissue. All of the above processes are much more active and efficient during sleep than when the body is active with increased metabolism, digestion of food, continuous daily activity.

Take human growth hormone, for example. The circadian supplement for accelerated muscle mass uses a natural acetylcholine receptor (AChR) agonist to stimulate quiescent adult stem cell mobilization, and combines it with amino acid, L-carnitine to reduce muscle damage from a hypoxic workout. The combination produces natural anabolic hormone release of human growth hormone, (HGH) insulin-like growth factor (I GF), insulin-like growth factor binding protein (IGFBP), and testosterone for the workout.

Although these growth factors and stem cells are stimulated during the workout, the real effect comes when they are again stimulated at night for maximum effectiveness.

When the workout is designed to exercise a specific muscle group (say, the pectorals) to exhaustion, the resulting hypoxic condition causes release of certain peptides called hypoxic inducible factor (HIF) that mobilize sleeping adult stem cells from the bone marrow which are recruited to the workout zone by stem-cell factors such as HIF and vascular endothelial growth factor (VEGF), nitric oxide (NO) synthase, and other unelucidated factors. Once stem cells are in the workout zone they immediately begin to replicate into identical muscle cells and build new blood vessels to supply nutrients to the new muscle-cell population. These juvenile muscle cells continue to multiply and mature into fully developed striated muscle cells.

The product is divided into two doses, one to take care of the workout needs for down regulation of inflammatory responses to micro-tears, strains and cell exhaustion, and an evening dose to induce gentle sleep while a new dose of muscle-building supplements is provided for complete tissue recovery and replenishing of protein stores.

The female product contains a natural estrogenic bio-identical hormone derived from Mexican Yam to reduce the exercise loss of fibro glandular tissue in the breast, while increasing the loss of adipose fat and omental fat in the belly, hips and thighs.

In summary, circadian dietary supplements are designed to take advantage of the circadian body rhythms and offer many advantages over conventional supplements designed for once-per-day use.

NEW METHOD FOR ‘GROWING’ DRUGS/MEDICINE

Background on Medicinal Mushrooms

Only recently has Western society found what Eastern cultures have long known for centuries, that fungi, especially mushrooms have within them some of the most potent nutritional substances and medicine found in nature. Their cellular constituents can profoundly improve the quality of human health. Differing from most pharmaceuticals, these healing agents have extraordinarily low toxicity, even at high doses. Acupuncture and the use of Traditional Chinese Medicine (TCM) are examples of East-West merger of medical treatments.

Fungi and animals share a more recent common ancestry than with plants, protozoan, and bacteria. Fungal medicine are therefore active against many diseases that afflict humans. Many scientists believe this relationship occurs because we are more closely related to fungi than to any other kingdom, having shared a common ancestor more than 460 million years ago, and thus developed defenses against mutual microbial enemies.

The healing properties of mushrooms has been widely documented in Western scientific research. For example, Cordyceps have anti-bacterial, anti-viral and anti-tumor properties and help regulate cholesterol and blood pressure. Maitakes have strong anti-candida properties and they greatly enhance the immune system. Reishi mushrooms have a wide variety of therapeutic effects, including but not limited to supporting liver and cardiovascular function as well as moderating blood sugar levels.

New Method For ‘Growing’ Medicine

Metabolic Research has developed a new proprietary technology that it believes could revolutionize the pharmaceutical industry by perfecting its method of growing non-toxic, safe and effective drugs using fungi vs. manufacturing them

Fungi have developed a unique capability to utilize their environment exclusively to adapt to survive in a total parasite-like form in nature. Fungi do this by taking in all of their required nutrients from their host environment. In other words, whatever nutrients are fed to fungi, that’s what fungi will build upon and produce more of. For example, if you wanted fungi to produce fatty acids, you would simply feed various liposterols to them.

Metabolic Research, Inc. has recently acquired a license for North America to a method that describes how various fungal products in their natural state could be induced to uptake the proper exogenous food materials into their metabolic processes. Through metabolization of these products, fungi could then produce a vast array of metabolic end-products with pharmaceutical-grade healing properties.

The details of these techniques and processes are proprietary. However, the process is called “submerged fermentation”, which greatly accelerates the growth of fungi. For example, growing mushrooms in a controlled environment such as hot houses requires approximately six weeks to grow Agaricus Blazei Murrill mushrooms to full maturity. Using submerged fermentation and the company’s newly developed method of “agitated propagation”, MRI can complete the process within 14 days.

TECHNOLOGY DESCRIPTION

A breakthrough discovery using fungi, plant, or animal sources to produce anti-inflammatory and analgesic products to both treat and cure inflammatory disease includes a Provisional Patent application titled: Composition and Method of Producing Endogenous Therapeutic Anti Inflammatory Eicosanoids and their Metabolites by Exogenous or Oral Means.

The above invention teaches the use of cyclooxidase- 2 (COX-2) inhibitors which are the most useful products discovered to date for down regulating, or blocking the arthritic producing enzyme COX-2. Both Merck and Bristol-Myers (CelebrexT) and VioxxT introduced pharmaceutical COX-2 blockers in the late 1990’s with enormous initial success. However due to the solvent nature of cyclic hydrocarbons on arterial plaques both products were removed from the market by the FDA in early 2001 and 2002 due to literally thousands of deaths due to fatal blood clots. The invention described above relies upon an entirely different and natural occurring hormone to reduce or block COX-2 induced inflammation.

Using the above citation as state of the “art” the two provisional patents are based on use of fungi to produce highly potent natural anti arthritics. Titled: Method and Process for Producing Metabolic Production from Fungi and Method and Process for Producing Lectin Products from Fungi the inventions synergistically incorporate two separate biological actions to treat and/or cure arthritic conditions.